Breath Test Products

Basics of 13C Breath Testing

Breath Tests are a new non-invasive technique, which offer real benefits to both patient and doctor. A range of tests is available to clinicians for gastro-intestinal and metabolic diseases. Breath Tests use metabolites labeled with a
non-radioactive isotope of carbon, which removes the environmental and safety concerns associated with radioactive materials, while obtaining definitive results.

A 13C Breath Test consists of the administration to a patient of a 13C labeled substrate that is metabolized by a specific enzyme system resulting in 13CO2 as the end product. To monitor the enzyme response, 13C enrichment is measured in breath CO2.

The total procedure of 13C Breath testing includes definition of the preparation of the patient before the test,
administration of the 13C labeled substrate, collection of breath samples, measurement of 13C enrichment in breath CO2 and calculation of an end result.

To detect the Helicobacter pylori bacteria in the stomach, the Urea-13C Breath Test is used.

Campro Scientific offers you a wide range of 13C-labeled compounds (or Breath Test Substrates) for application in the following breath tests. Download Campro Brochures pfeil

 
Basics of H2 and CH4 Breath Testing

Hydrogen and methane are produced in the digestive system primarily only by the bacterial fermentation of carbohydrates (sugars, starches or vegetable fibers), so either of these gases appear in the expired air, it is usually a signal that carbohydrates or carbohydrate fragments have been exposed to bacteria, permitting such fermentation to take place.
 Bacteria are ordinarily not present in significant numbers in the small intestine, where digestion and absorption of sugars take place. Therefore, when a challenge dose (eg. lactose) is ingested, the level of hydrogen in alveolar air will rise significantly within one to two hours (depending on the intestinal transit time) only if the sugar is not digested and, therefore reaches the colon.
 

Function Test

• Gastro intestinal function
   - Digestion
   Carbohydrate Digestion
   13C Lactose high enriched
   13C Lactose natural enriched
   13C Sucrose
   13C Starch
   Lipid Digestion
   13C Triolein
   13C Tripalmitin
   13C Tristearin

   - Absorption
   Carbohydrate Absorption
   13C D-Glucose
   13C D-Fructose
   13C D-Galactose
   Fatty Acid Absorption
   13C Palmitic Acid
   13C Stearic Acid
   13C Linoleic Acid

• Liver function
   13C Aminopyrine
   13C Methacetin
   13C Ketoisocaproic Acid
   13C Phenacetin
   13C D-Galactose
   13C Caffein

• Pancreatic function
   13C Mixed Triglyceride
   13C Cholesteryl Octanoate
 

Gastro Intestinal Transit

• Gastric emptying rate
   - Solid Fase
   13C Octanoic Acid

   - Liquid Fase
   13C Sodium Octanoate
   13C Sodium Acetate
   13C Glycine
   

• Oro-cecal transit time
   13C Lactosyl Ureide
 

Bacterial Implication

• Helicobacter pylori
  13C Urea

• Small bowel bacterial overgrowth
  13C D-Xylose
  13C Cholylglycine
 

Metabolism

• Amino acid metabolism
  13C Leucine

• Fatty acid oxidation
  13C Linolenic Acid

 ° Breath Test Analysers

13C Breath Test Analysers

• HeliFANplus
• FANci2
• HeliFANplus with Autosampler
 

H2 / CH4 Breath Test Analysers

• Breath Test Samplers
 - GaSampler Kit
 - AlveoSampler Kit
 - EasySampler Kit